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doi: 10.3389/fcell.2021.682143 Received 17 March 2021 Accepted 24 June 2021 Published 26 July 2021 Volume 9 - 2021 Edited by Kai Kretzschmar, University Hospital Würzburg, Germany Reviewed by Ophir D

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(Feng et al., 2019) found that Tan IIA reduces the levels of tumor necrosis factor-α (TNF-α), IL-6, and IL-1β, inhibits the expression of type I collagen, FN, and α-SMA, and decreases the expression levels of TGF-β1, p-Smad2/3, and p-Smad3 while up-regulating the expression of Smad7 in the lung tissue of a rat model of silica-induced pulmonary fibrosis